P-005 Association between aging and semen parameters: a retrospective study on over 2,500 men

Abstract Study question Is there an association between advancing male age and worsening seminal parameters (If so, is it possible to define age-threshold for semen quality decline)? Summary answer Only sperm morphology motility-related exhibited a significant negative with age, particularly from the of 40 years. What known already While importance advanced maternal on reduced fertility higher reproductive risks well documented, scarce controversial are information regarding role aging potential. Indeed, growing concerns arise trend in average parenthood Western countries. design, size, duration A retrospective study was conducted 11,307 consecutive samples obtained men who attended Andrology Unit University Hospital L’Aquila, during period January 1992 2022 evaluation their Participants/materials, setting, methods Semen were collected by masturbation into sterile containers after sexual abstinence 2-7 days. Total count (TSC) calculated multiplying concentration volume ejaculate, motile (MSC) progressive motility (%), total (TMSC) MSC volume. Leukocytospermia defined as > 1x106 peroxidase-positive cells/mL. Main results chance Three hundred forty-nine patients azoospermia or severe oligozoospermia (<5x106 spz/ml) excluded. Moreover, 8,450 excluded because they only subjected analysis without concomitant clinical evaluation. Therefore, 2,508 subjects have been included final analysis. Significant inverse correlations observed (p=0.04), (p<0.0001) (p<0.0001), TMSC (p=0.01), (p=0.008), percentage spermatozoa normal (p=0.001), but not (p=0.8) TSC (p=0.2). After adjustment time, smoking, history genital tract infections, trauma, varicocele, cryptorchidism, orchiectomy, year analysis, found (p=0.0003), (p=0.035). The comparison among quartiles revealed that group above years associated reduction motility, motile, count, while decline forms appeared be earlier. Limitations, reasons caution present did analyze couple outcomes. since DNA fragmentation available limited number subjects, assess its aging. Wider implications findings In light oxidative stress affecting aged over 40, optimization paternal lifestyle combined targeted antioxidants treatments could valuable preventive tools infertility work-up. Trial registration applicable